mRNA-based vaccines and therapeutics offer a promising approach to addressing unmet needs in disease prevention and treatment. Explore a simple, robust workflow for IVT, the gold standard method for large-scale production of mRNA drug substances.

Discover how IVT streamlines plasmid purification, RNA production, and quality control of the purified nucleic acids.

Download the application note for data-rich information about:

  • An automated workflow for IVT of mRNA
  • Automated plasmid purification and quality control
  • Plasmid-directed IVT of RNA on magnetic beads (solid-phase IVT)
  • Quality control of purified RNA by direct sequencing and quantification by PCR
  • Precise measurement of residual template DNA in purified RNA samples by dPCR
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